Why It's Important: Among other things, the TREM2 protein is involved with phagocytosis by microglia.
Relating a variant in this gene/protein to AD strongly supports the involvement of microglia and the immune system in the pathogenesis of this important disease and also adds another factor to genetic risk for AD.
This lesson will define a fossil, look at different types and characteristics of fossils, and then describe how fossils are formed.
This article provides the evidence for doing so and shows how it improves the quality of care we give our patients, particularly in the areas of complex symptom management — for example, treating non-pain symptoms such as nausea, delirium, and fatigue; communication (that is, responding to emotion and demonstrating empathy); establishing goals of care; and facilitating medical decision-making.
Results: Using different approaches, two groups independently found that a variant (R47H) in the TREM2 (triggering receptor expressed on myeloid cells 2 protein) gene is a rare but strong genetic risk factor for late-onset Alzheimer's disease (AD) in the general population.
Generally when relatively dating strata or fossils in strata the oldest material will be below the newest material which means oldest on the bottom and newest on the top.
Think of making a brick-wall, the first bricks to be put down are those on the bottom which makes them older than those at the top of the wall.