Drug expiration dating calculations

The calculator has been field tested by veterinary technicians within the University of California, San Francisco (UCSF) Laboratory Animal Resource Center on a range of mouse cases.

The Challenges of Compounding Commercially produced preparations of drugs in concentrations ideal for mice are not readily available.

Animal size is a crucial variable because relatively small injection volumes and the high variability of mouse weights, particularly in older animals, allows for a greater likelihood of inadvertent under- or overdosing.

The calculator file is divided between two sheets: “Calculator” serves as the user interface, requiring inputs and displaying instructions on how to prepare drugs; and “Formulary” includes the raw data such as stock concentrations and other internal metrics.

The Mouse Dosage Calculator is free to download from the IACUC formulary page of the UCSF Web site.

A standard laboratory animal formulary for all anesthetic and analgesic agents used in this calculator is available online at the UCSF IACUC Web site.

As indicated within its notes section, modifying the Formulary sheet is advised against unless the user’s stock drug concentrations differ from those in the calculator; users may modify this sheet to resolve the disparity.

However, concentrations outside those recommended have not been tested, so we are unable to guarantee the calculator’s effectiveness if the Formulary sheet is altered.

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